Powder: -20°C for 3 years | In solvent: -80°C for 1 year
4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物,是一种酶抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 259 | 现货 | ||
100 mg | ¥ 372 | 现货 | ||
500 mg | ¥ 883 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 397 | 现货 |
产品描述 | 4-Hydroxyphenylpyruvic acid is an enzyme inhibitor.4-Hydroxyphenylpyruvic acid (4-HPPA) is a keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase (EC 1.1.1.222) and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. Additionally, 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. The enzyme 4-hydroxyphenylpyruvic acid dioxygenase (HPD) catalyzes the reaction that converts 4-hydroxyphenylpyruvic acid to homogentisic acid. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine. It has been shown that hawkinsinuria, an autosomal dominant disorder characterized by the excretion of 'hawkinsin,' may also be a result of HPD deficiency . Moreover, 4-hydroxyphenylpyruvic acid is also found to be associated in phenylketonuria, which is also an inborn error of metabolism. There are two isomers of HPPA, specifically 4HPPA and 3HPPA, of which 4HPPA is the most common. |
别名 | 4-羟苯基丙酮酸, 4-Hydroxyphenylpyruvic acid |
分子量 | 180.16 |
分子式 | C9H8O4 |
CAS No. | 156-39-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (277.53 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 5.5506 mL | 27.7531 mL | 55.5062 mL | 138.7655 mL |
5 mM | 1.1101 mL | 5.5506 mL | 11.1012 mL | 27.7531 mL | |
10 mM | 0.5551 mL | 2.7753 mL | 5.5506 mL | 13.8766 mL | |
20 mM | 0.2775 mL | 1.3877 mL | 2.7753 mL | 6.9383 mL | |
50 mM | 0.111 mL | 0.5551 mL | 1.1101 mL | 2.7753 mL | |
100 mM | 0.0555 mL | 0.2775 mL | 0.5551 mL | 1.3877 mL |
中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
黎檬叶 | CitruslimoniaOsbeck | 温 | 辛, 甘 | 肺, 胃, 大肠 |
柠檬叶 | Citrus limonia Osbeck, Citrus limon(L.)Burm.f. | 微温 | 辛, 甘, 微苦 | 肺, 胃, 大肠 |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
4-Hydroxyphenylpyruvic acid 156-39-8 Metabolism Endogenous Metabolite inhibit 4 Hydroxyphenylpyruvic acid 4-羟苯基丙酮酸 4Hydroxyphenylpyruvic acid 4-Hydroxyphenylpyruvic acid 4-?Hydroxyphenylpyruvic acid Inhibitor inhibitor